Blood tests Fine-Tune leukemia drug combo to cut infection risk

This study looked at 15 older adults with acute myeloid leukemia (AML) who were getting a standard drug combo (azacitidine or decitabine plus venetoclax). Because these drugs can lower infection-fighting white blood cells, patients often take an antifungal called posaconazole. The problem is posaconazole can raise venetoclax levels too high, causing more side effects. Researchers measured venetoclax in the blood to see how many patients reached a stable, safe level by day 12, aiming to guide proper dosing.