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Which drug keeps the brain safer during surgery? new study aims to find out

NCT ID NCT06083948

Knowledge-focused Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests two common blood-pressure-raising drugs, noradrenaline and phenylephrine, in 32 people undergoing brain tumor surgery. The goal is to see which drug better maintains blood flow and oxygen delivery to the brain and other organs. Researchers will use PET scans to measure these effects. The results may help anesthesiologists choose the best drug for future surgeries.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Noradrenaline and phenylephrine (drugs to raise blood pressure)
What this could lead to
If successful, this could help doctors choose the best drug to protect the brain and organs during surgery.
What could go wrong
This is a small, early-phase study with only 32 patients, so results may not apply to everyone. It measures blood flow, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 32 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI). 2. Scheduled for elective supratentorial craniotomy. 3. Patients aged between 18 and 75 years. 4. American Society of Anesthesiologists status 1-3 Exclusion Criteria: 1. History of allergy or intolerance to one of the study medications. 2. Active treatment with monoamine oxidase inhibitors. 3. An American Society of Anesthesiologists (ASA)physical status IV-VI. 4. Pregnancy or breastfeeding. 5. Inability to provide written informed consent -

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Conditions

The condition(s) this trial relates to.

hypotensive disorder supratentorial cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypotension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aarhus University Hospital

    RECRUITING

    Aarhus, 8200, Denmark

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