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Can freezing nerves stop phantom limb pain?

NCT ID NCT06908538

Symptom relief Sponsor: AtriCure, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 27, 2026 · Updated 2 times

Summary

This study is tracking how well freezing nerves during amputation surgery works to reduce pain after the operation and phantom limb pain. Researchers will follow 2000 adults who are having an arm or leg amputated. The goal is to see if this nerve-freezing technique is safe and helpful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryoablation (nerve freezing via a probe)
What this could lead to
If successful, this could provide a way to reduce severe pain after amputation, including phantom limb pain, without long-term medication.
What could go wrong
This is an observational registry, not a controlled trial, so it cannot prove the treatment works. The nerve block is temporary (weeks to months), and pain may return. Risks include procedural complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Apr 2035

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects who have or will have an amputation procedure.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who have or will have an amputation procedure; * Patients who are willing and capable of providing informed consent; * Patients whose age is 18 years or above, or of legal age to give informed consent specific to state and national law. Exclusion Criteria: * Women of childbearing potential who are, or plan to become, pregnant during the time of the study; * Other medical, social, or psychological conditions that in the opinion of the Investigator precludes the subject from appropriate consent or adherence to the protocol.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amputation Amputation of lower limb Amputation of upper limb Amputation, limb loss Amputation, traumatic/surgery Cryo analgesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Berkshire Medical Center

    RECRUITING

    Pittsfield, Massachusetts, 01201, United States

  • Elliot Hospital

    RECRUITING

    Manchester, New Hampshire, 03101, United States

  • Medical College of Wisconsin/Froedtert Hospital

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • NYU Langone Health

    RECRUITING

    New York, New York, 10017, United States

  • Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Prisma Health - Upstate

    RECRUITING

    Greenville, South Carolina, 29605, United States

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