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Can jumping and lifting at home save hip bone in amputees?

NCT ID NCT07817381

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

People with a below-knee amputation often lose bone density in the hip, which raises the risk of fractures. Researchers are testing a home exercise program that combines resistance moves like squats and deadlifts with jumping activities. Ten men who use a prosthetic limb will try the program for eight weeks, with remote supervision, to see whether it is safe and practical to carry out. The study also measures changes in hip strength and movement performance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a home-based resistance and high-impact exercise program supervised remotely
What this could lead to
If it proves safe and practical, this could shape rehabilitation programs that help people with lower-limb amputations protect their hip bone density and lower their fracture risk.
What could go wrong
This is a very small, early-stage study of 10 men, so it cannot show whether the exercise actually strengthens bone. The jumping and lifting could also cause discomfort or injury, which is why safety is a key focus.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current or previous British Armed Forces Personnel who are members of the ADVANCE Study (Bennett et al., 2020) * Male * Aged ≥ 18 years and ≤ 55 years * History of unilateral below knee limb loss due to trauma * Ambulating with their current prosthetic limb for a minimum of six months * Full-time prosthesis wearer (i.e., wearing the prosthesis every day, for most of the day, removing it mainly for sleeping or when resting for extended periods) * Able to walk independently using a prosthetic limb * Able to perform jumping activities on the prosthetic limb * Able to communicate in English * Access to the internet and a computer/smartphone * Able to drive/be driven to and from the testing location for the purpose of transporting the exercise equipment provided by the research team Exclusion Criteria: * Additional limb loss of the upper and/or lower limb other than the transtibial limb loss * Cardiovascular disease, diabetes, neurological injury * Sickle cell disease * Neurodegenerative disease * Limb loss as a result of a vascular condition * Orthopaedic or neurological issues in the intact/non-amputated limb * Additional neuromusculoskeletal pathology which may affect walking * Pain, irritation, swelling, or skin complaints in the residual limb which inhibit prosthetic use * Diseases affecting bone metabolism (other than osteoporosis/osteopenia; for example, osteomalacia, Paget's disease, hyper/hypoparathyroidism, osteogenesis imperfecta) * Traumatic head injury resulting in cognitive disability * Lack of capacity to give consent * Any contraindications to exercise and/or resistance training * Continuous immobilisation for seven days or more in the month prior to attendance * Use of assistive walking device when utilising the, other than a prosthetic limb * Unable to regularly attend the supervised training program

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Conditions

The condition(s) this trial relates to.

Amputation, Traumatic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Defence Medical Rehabilitation Centre, Stanford Hall

    RECRUITING

    Loughborough, United Kingdom

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