Can jumping and lifting at home save hip bone in amputees?
NCT ID NCT07817381
First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time
Summary
People with a below-knee amputation often lose bone density in the hip, which raises the risk of fractures. Researchers are testing a home exercise program that combines resistance moves like squats and deadlifts with jumping activities. Ten men who use a prosthetic limb will try the program for eight weeks, with remote supervision, to see whether it is safe and practical to carry out. The study also measures changes in hip strength and movement performance.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a home-based resistance and high-impact exercise program supervised remotely
- What this could lead to
- If it proves safe and practical, this could shape rehabilitation programs that help people with lower-limb amputations protect their hip bone density and lower their fracture risk.
- What could go wrong
- This is a very small, early-stage study of 10 men, so it cannot show whether the exercise actually strengthens bone. The jumping and lifting could also cause discomfort or injury, which is why safety is a key focus.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Current or previous British Armed Forces Personnel who are members of the ADVANCE Study (Bennett et al., 2020) * Male * Aged ≥ 18 years and ≤ 55 years * History of unilateral below knee limb loss due to trauma * Ambulating with their current prosthetic limb for a minimum of six months * Full-time prosthesis wearer (i.e., wearing the prosthesis every day, for most of the day, removing it mainly for sleeping or when resting for extended periods) * Able to walk independently using a prosthetic limb * Able to perform jumping activities on the prosthetic limb * Able to communicate in English * Access to the internet and a computer/smartphone * Able to drive/be driven to and from the testing location for the purpose of transporting the exercise equipment provided by the research team Exclusion Criteria: * Additional limb loss of the upper and/or lower limb other than the transtibial limb loss * Cardiovascular disease, diabetes, neurological injury * Sickle cell disease * Neurodegenerative disease * Limb loss as a result of a vascular condition * Orthopaedic or neurological issues in the intact/non-amputated limb * Additional neuromusculoskeletal pathology which may affect walking * Pain, irritation, swelling, or skin complaints in the residual limb which inhibit prosthetic use * Diseases affecting bone metabolism (other than osteoporosis/osteopenia; for example, osteomalacia, Paget's disease, hyper/hypoparathyroidism, osteogenesis imperfecta) * Traumatic head injury resulting in cognitive disability * Lack of capacity to give consent * Any contraindications to exercise and/or resistance training * Continuous immobilisation for seven days or more in the month prior to attendance * Use of assistive walking device when utilising the, other than a prosthetic limb * Unable to regularly attend the supervised training program
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Defence Medical Rehabilitation Centre, Stanford Hall
RECRUITINGLoughborough, United Kingdom
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