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Spine surgery infection breakthrough? vancomycin powder tested in new trial

NCT ID NCT03839914

Disease control Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether placing vancomycin powder directly into the wound during spine surgery can prevent infections in high-risk patients, such as those with spinal deformities or tumors. Half of the 76 adult participants will receive the powder, while the other half will not. The goal is to see if this simple addition reduces surgical site infections without causing serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vancomycin powder
What this could lead to
If it works, this could provide a simple, cost-effective way to lower infection rates after high-risk spine surgery.
What could go wrong
This is a small, early-stage trial with only 76 participants. The results may not apply to all patients, and there is a risk of side effects like kidney problems or antibiotic resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 76 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2020

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Female or male adult with age ≥18 years 2. Undergoing open posterior spinal surgery with instrumentation indicated for spinal deformity, trauma and tumor 3. Able to understand the nature, scope and possible consequences of participation in the study 4. Appropriate voluntary written informed consent have been provided by patients Exclusion Criteria: 1. Has been treated with antibiotics due to primary spinal infection (i.e. spondylodiscitis) within 1 year prior to surgery 2. Ongoing treatment with antibiotics for other infections 3. Undergoing minimally invasive surgery or anterior-only surgical approaches or deformity correction surgery for adolescent idiopathic scoliosis (inherent low-risk for surgical site infections18) 4. Undergoing decompression-only surgery for cervical spine, spinal deformity, trauma and tumors 5. Has known history of allergy to vancomycin, penicillin and other glycopeptides (teicoplanin) 6. Has history of vancomycin resistance 7. Pregnancy

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Conditions

The condition(s) this trial relates to.

injury spinal cord cancer spinal cord neoplasm spinal injury Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal deformity Spinal tumor Surgical site infection Trauma

Contacts and locations

Locations

  • Queen Mary Hospital

    Hong Kong, Hong Kong

More trials for these conditions

Other studies related to the condition(s) this trial covers.