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Ear zaps and exercise show promise for lupus fatigue

NCT ID NCT07256067

First seen Jan 06, 2026 · Last updated Jun 22, 2026 · Updated 26 times

Summary

This study tested whether a device that gently stimulates a nerve in the ear, combined with aerobic exercise, can reduce fatigue in women with lupus. Fifty women aged 35 to 55 took part, with half receiving the real stimulation and half a sham version, both alongside their usual medical care. The treatment was given three times a week for six weeks. The goal was to see if this approach could improve fatigue severity and walking ability.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • faculty of Physical Therapy

    Giza, Egpt, 12613, Egypt

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

transcutaneous vagus nerve stimulation (tVNS) device

What this could lead to

If it works, this could offer a drug-free way to reduce fatigue and improve daily function for people with lupus.

What could go wrong

This is a small, early-stage trial with only 50 participants. The results may not apply to all lupus patients, and the effect might be modest or due to the exercise alone.

Conditions

The condition(s) this trial relates to.

Fatigue systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.