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Scientists probe UV's hidden immune trick in skin

NCT ID NCT05020496

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This study looks at how ultraviolet (UV) light from the sun can weaken the immune system in human skin, which may help explain how skin cancer develops. Researchers will apply a chemical called DPCP to the skin of 70 healthy adults aged 18-35 to trigger a mild allergic reaction and measure immune responses. The goal is to uncover new details about UV's effects, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Diphenylcyclopropenone (DPCP) applied topically
What this could lead to
If successful, this could reveal new ways UV light weakens skin immunity, potentially pointing toward future strategies to prevent skin cancer.
What could go wrong
This is a very early, small study focused on understanding mechanisms, not testing a treatment. Results may not lead to any direct medical application.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2022

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Inclusion Criteria * Patient age 18-35 * Patient able to understand requirements of the study and risks involved * Patient able to sign a consent form Exclusion Criteria: * Patients Fitzpatrick IV-VI * A recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post inflammatory hyperpigmentation * Patients with eczema, psoriasis, and contact dermatitis * A known history of photosensitivity disorders * A known history of melanoma or non-melanoma skin cancers * Those planning on going to the tanning parlors * Using any of the photosensitizing medication * A woman who is lactating, pregnant, or planning to become pregnant * Patient planning on exposing the irradiated or control areas to the sun * Patients with organ transplantation, an immunodeficiency disorder or the use of an immunosuppressive drug

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Conditions

The condition(s) this trial relates to.

skin disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Skin diseases

Contacts and locations

Locations

  • Whitaker Clinic

    Birmingham, Alabama, 35294, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.