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1,000 volunteers needed to unlock secrets of sickle cell trait

NCT ID NCT06071377

Knowledge-focused Sponsor: National Alliance for Sickle Cell Centers Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will follow 1,000 adults who have sickle cell trait (SCT) to better understand how it affects their health. Researchers will collect blood and urine samples to measure hemoglobin levels, blood cell properties, and signs of kidney or clotting problems. The goal is to learn why some people with SCT develop complications while others do not.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal which people with sickle cell trait are at higher risk for health problems like kidney disease, helping doctors monitor them better.
What could go wrong
This is an observational study, not a treatment trial. It will not test any drug or therapy, so it cannot directly improve health. Results may take years and might not lead to clear changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2023

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults aged 18 and older with sickle cell trait.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Are willing to voluntarily participate and sign the study consent 2. Know/suspect they have SCT and are willing to get tested to confirm/learn about their SCT status 3. Adults ages 18 and older Exclusion Criteria: 1. Unwilling to sign consent 2. Known end-stage renal disease or dialysis 3. Known SCD (including sickle cell-beta thalassemia) 4. People who do not have SCT

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Conditions

The condition(s) this trial relates to.

Sickle Cell Trait

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sickle cell trait

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    10 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Duke University

    RECRUITING

    Durham, North Carolina, 27710, United States

  • East Carolina University

    RECRUITING

    Greenville, North Carolina, 27834, United States

  • Functional Fluidics

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Indiana University

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Loma Linda University Health Care

    RECRUITING

    Loma Linda, California, 92354, United States

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

  • Nemours Children's Hospital

    RECRUITING

    Wilmington, Delaware, 19803, United States

  • UT Health Houston

    RECRUITING

    Houston, Texas, 77030, United States

  • University of Alabama

    RECRUITING

    Birmingham, Alabama, 35294, United States

  • University of North Carolina

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

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