Can your Brain's expectations fool you? Parkinson's hallucination study seeks answers
NCT ID NCT07427498
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This observational study will examine whether prior expectations increase false perceptions in Parkinson's patients who experience visual hallucinations. About 60 participants, including patients with and without hallucinations and healthy volunteers, will complete a computer-based face detection task and cognitive tests. The goal is to better understand the mechanisms behind hallucinations in Parkinson's disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help explain why some Parkinson's patients experience hallucinations, potentially guiding future therapies.
- What could go wrong
- This is an early observational study with only 60 participants, so results may not apply broadly. It does not test any treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Nov 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study will recruit Parkinson's disease patients (disease duration ≥1 year, no major cognitive impairment) from CHU Grenoble-Alpes, including 15 with minor hallucinations (e.g., passage/presence sensations) and 15 with major hallucinations (e.g., complex visual hallucinations). Patients with active psychosis are excluded. Healthy volunteers (matched by age, gender, and education) will be recruited via ads in senior associations and affiliated institutions (CHUGA, GIN). Matching tolerates ±5 years for age and ±2 years for education; those without a high school diploma will be matched without strict education criteria. Ads may also appear on institutional websites.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults diagnosed with Parkinson's disease (with or without visual hallucinations) or healthy volunteers. * Age 18 - 85 years. * Consent to participate. Exclusion Criteria: * Currently participating in another clinical or therapeutic trial involving the testing of a drug treatment. * Inability to perform cognitive tests due to: Non-psychiatric (somatic) conditions likely to affect cognitive abilities. Peripheral sensory or motor deficits. Acute clinical conditions (e.g., agitation, impaired consciousness). * Diagnosis of dementia. * Individuals covered by Articles L1121-5 to L1121-8 of the French Public Health Code (Code de la Santé Publique), including: Pregnant women, women in labor, or breastfeeding mothers. Individuals deprived of liberty by judicial or administrative decision. Individuals receiving psychiatric care under Articles L. 3212-1 and L. 3213-1 (excluding those covered by Article L. 1121-8). Individuals admitted to a healthcare or social institution for purposes other than research. Minors or adults under legal guardianship or unable to express consent. \- Individuals with a hierarchical relationship to any professional involved in the study. Only for healthy volunteers: \- Personal history of diagnosed neurological disorders. Post-Inclusion Exclusion: \- Participants included in the study but found to have a MoCA score below 24 will be excluded from the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Grenoble University Hospitals
La Tronche, France
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