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Study aims to unlock secrets of lung failure in kids

NCT ID NCT04113434

Knowledge-focused Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 513 children with a severe lung condition called ARDS to find different subtypes of the disease. Researchers collected blood samples to measure proteins and gene activity. The goal was to better understand the disease and help design more targeted treatments in the future.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

513 people

The number who actually took part.

Started

Jan 2020

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Infants to adolescents between the ages of 44 weeks and 17.5 years, who are admitted to PICU for acute respiratory failure requiring invasive mechanical ventilation.

Ages

44 weeks to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. acute (≤ 7 days of risk factor) respiratory failure requiring invasive mechanical ventilation 2. age \> 44 weeks corrected gestational age and \< 17.5 years 3. invasive mechanical ventilation via endotracheal tube 4. bilateral infiltrates on chest radiograph 5. oxygenation index (OI) ≥ 4; or oxygen saturation index (OSI) ≥ 5 on 2 consecutive measurements at least 4 hours apart but \< 24 hours apart 6. invasively ventilated ≤ 7 days before meeting above radiographic and oxygenation criteria Exclusion Criteria: 1. weight \< 3 kilograms 2. cyanotic congenital heart disease (other than Patent Foramen Ovale (PFO) or Patent Ductus Arteriosus (PDA)) 3. tracheostomy at time of screening 4. invasively ventilated for \> 7 days when meet ARDS criteria above 5. cardiac failure as predominant cause of respiratory failure 6. primary obstructive airway disease (asthma, bronchiolitis) by judgement of clinician as the primary cause of respiratory failure 7. alternative known chronic lung disease as cause of respiratory failure (cystic fibrosis, eosinophilic pneumonia, interstitial pneumonitis, pulmonary hemosiderosis, cryptogenic organizing pneumonia) 8. severe neurologic morbidity not expected to survive \> 72 hours 9. any limitations of care at time of screening 10. previous enrollment in this study

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute respiratory distress syndrome

Contacts and locations

Locations

  • Akron Children's Hospital

    Akron, Ohio, 44308, United States

  • Arkansas Children's Hospital

    Little Rock, Arkansas, 72202, United States

  • Children's Healthcare of Atlanta - Emory

    Atlanta, Georgia, 30322, United States

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Children's Mercy Hospital

    Kansas City, Missouri, 64108, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Columbia University Medical Center

    New York, New York, 10032, United States

  • Cooperman Barnabas Medical Center

    Livingston, New Jersey, 07039, United States

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Penn State Hershey Children's Hospital

    Hershey, Pennsylvania, 17033, United States

  • Riley Children's at Indiana University Health

    Indianapolis, Indiana, 46202, United States

  • Texas Children's Hospital / Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Variety Children's Hospital D/B/A Nicklaus Children's Hospital

    Miami, Florida, 33155, United States

  • Washington University

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.