Sound waves could open Brain's barrier to fight Kids' cancer
NCT ID NCT05293197
First seen Nov 20, 2025 · Last updated Jun 22, 2026 · Updated 21 times
Summary
This early-stage trial tests whether an implanted ultrasound device called SonoCloud-9 can safely open the blood-brain barrier in children with recurrent malignant brain tumors. The idea is to let chemotherapy (carboplatin) reach the tumor more effectively. The study involves 24 children aged 5 to 17 and focuses on safety, not yet on curing the disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Institut Curie
RECRUITINGParis, 75005, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institut Gustave Roussy
RECRUITINGVillejuif, 94800, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Service de neurochirugie Pédiatrique - Hôpital Necker- Enfants Malades
RECRUITINGParis, 75015, France
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SonoCloud-9 ultrasound device
What this could lead to
If it works, this could make chemotherapy more effective for children with hard-to-treat brain tumors by temporarily opening the blood-brain barrier.
What could go wrong
This is a very early phase 1 trial with only 24 children, so safety and effectiveness are not yet proven. There are risks like bleeding or brain swelling from the ultrasound.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.