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Olive oil nutrient and creatine team up to fight fatigue in new study

NCT ID NCT06883292

Symptom relief Sponsor: Applied Science & Performance Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed trial tested whether tyrosol (a compound found in olive oil) and creatine, alone or together, can improve endurance, strength, and fatigue resistance in healthy adults. Fifty active men and women aged 18–50 took supplements or a placebo for about 4 weeks. They completed a series of physical and cognitive tests before and after supplementation to measure any changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tyrosol and creatine monohydrate
What this could lead to
If it works, this could point toward a simple supplement combination to improve physical performance and recovery in active people.
What could go wrong
This is a small, completed trial in healthy adults, not a patient population. Results may not apply to others, and supplements often show limited real-world benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Mar 2025

Finished

Aug 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy males or females aged 18-50 * Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines) * Estimated VO2 max equal to or greater than the 50th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005). * Able to read and write in English * During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine). * Females willing to share days menstrual cycle for testing purposes as shifts in hormone levels may, potentially, affect testing Exclusion Criteria: * Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease * Recent musculoskeletal injury (\<3-months) * Recent orthopaedic surgery (\<12-months) * History or current malignancy * Previous gastrointestinal surgery within the past 12 months * Regular smoker * Regular drinker (\>14 drinks per week) * Current use (within the past 4 weeks) of creatine supplements * Current use (within past 3 months) of Tyrosol supplementation * Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.). * Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.) * Female subjects who do not test negative on a urine pregnancy test or are lactating.

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Conditions

The condition(s) this trial relates to.

cognitive disorder tyrosinemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognition Creatine Endurance performance Tyrosol

Contacts and locations

Locations

  • Applied Science & Performance Institute

    Tampa, Florida, 33634, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.