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Booster shot for typhoid: could it protect kids for years?

NCT ID NCT07624175

Disease control Sponsor: Kathleen Neuzil Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a booster dose of typhoid vaccine given 5-6 years after the first shot still works in children. Researchers measured immune responses and side effects in 147 children in Burkina Faso. The goal is to understand how long protection lasts and if boosters are needed in areas where typhoid is a serious threat.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
typhoid conjugate vaccine (Vi-CRM)
What this could lead to
If successful, this could show that a booster dose of typhoid vaccine provides lasting protection for children in areas where typhoid is common.
What could go wrong
This is a small, completed Phase 2 study with 147 children, so results may not apply to larger populations. The vaccine may not provide long-term immunity or may cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

147 people

The number who actually took part.

Started

Aug 2024

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 7 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female children previously enrolled in the 2018-2019 Phase 2 typhoid conjugate vaccine trial * Residence within study area * Parent/guardian provides informed consent Exclusion Criteria: * Receipt of blood products within 6 months * Prior typhoid conjugate vaccine receipt outside the study * Medical condition interfering with evaluation * Acute illness or fever prior to vaccination (temporary exclusion)

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Conditions

The condition(s) this trial relates to.

typhoid fever prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Typhoid

Contacts and locations

Locations

  • Schiphra Protestant Hospital

    Ouagadougou, Burkina Faso

More trials for these conditions

Other studies related to the condition(s) this trial covers.