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Which antibiotic works faster for typhoid in kids?

NCT ID NCT07150065

Disease control Sponsor: Avicenna Medical College Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This completed Phase 2 trial tested two antibiotics, levofloxacin and ciprofloxacin, in 360 children aged 1-12 with typhoid fever. The goal was to see which drug resolves fever faster within 5 days. Children were randomly assigned to one of the two drugs and monitored in the hospital for a week.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
levofloxacin and ciprofloxacin
What this could lead to
If levofloxacin works better, it could offer a simpler, shorter treatment option for children with typhoid fever.
What could go wrong
This is a small, completed Phase 2 trial, so results may not apply to all children. Both drugs are antibiotics, and overuse can lead to resistance.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

360 people

The number who actually took part.

Started

Feb 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 year to 12 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children of age 1-12 years * Typhoid fever * Confirmed on blood culture Exclusion Criteria: * Recurrent typhoid within 3 months * Intestinal perforation * Evidence of progressive or complicated disease * Inability to swallow oral medication * Hypersensitivity to trial drugs * Already taken fluoroquinolone, third generation cephalosporin or macrolide in last week

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Conditions

The condition(s) this trial relates to.

Fever typhoid fever

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fever Typhoid

Contacts and locations

Locations

  • Avicenna Hospital Lahore

    Lahore, Punjab Province, 54000, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.