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Can exercise plus brain training help cancer survivors? small study aims to find out

NCT ID NCT06989463

Knowledge-focused Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study looks at whether adult survivors of childhood cancer will take part in two health programs at the same time. Participants will either do exercise plus cognitive training (brain games) or exercise plus mindfulness practice over 12 weeks. The goal is to see if people find this acceptable and stick with it, not yet to measure health improvements.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise, cognitive training, and mindfulness practice
What this could lead to
If successful, this could show that combining exercise with brain training or mindfulness is a practical way to help cancer survivors manage thinking problems or emotional distress.
What could go wrong
This is a very small pilot study (20 people) focused on whether people will stick with the program, not on whether it works. It may not lead to clear health benefits or apply to all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jul 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants enrolled in St. Jude Lifetime Cohort (SJLIFE) \>18 years of age. * Participant has been pre-identified as both physically impaired (T score ≤45 on the physical function and/or role physical subscales of the Medical Outcomes Survey Short Form 36 (SF-36)), and either cognitively (standard score \>84th percentile on the Childhood Cancer Survivor Study Neurocognitive Questionnaire) or emotionally impaired (T scored score ≥ 63 on the Brief Symptom Inventory) from the most recently completed SJLIFE survey questionnaires. * Participant self-reports participating in \<150 minutes of moderate to vigorous physical activity per week (Centers for Disease Control Physical Activity Guidelines for Americans). * Participant has been medically cleared to participate in physical activity. * Participant verbalizing understanding of the directions to use the digital platform on provided laptop/tablet. Exclusion Criteria: * Participant cannot speak, read, and/or understand English. * Participant is a woman and currently pregnant. * Participant reports engaging in mindfulness-based training or continuously practiced mindfulness techniques over the past 6 weeks. * Participant has an estimated intelligence score (FSIQ) \<80. * Participant has a diagnosis of post-traumatic stress disorder, major psychiatric condition, and/or history of suicidal ideation or self-harm. * Participant reports alcohol or drug abuse in the past year (Alcohol Use Disorders Identification Test (AUDIT) \>=13/women and \>=15/men or Drug Abuse Screen Test (DAST) -10\>3).

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Conditions

The condition(s) this trial relates to.

childhood malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Survivors of childhood cancer

Contacts and locations

Locations

  • St. Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.