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Could a gentle ear zap tame POTS?

NCT ID NCT07163130

Symptom relief Sponsor: Aristotle University Of Thessaloniki Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a device that stimulates a nerve in the ear to see if it can help people with POTS, a condition that causes a racing heart and dizziness when standing. Twenty-four adults with POTS will receive both active and sham stimulation in a crossover design. The main goal is to measure changes in heart rate during a standing test.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcutaneous auricular vagus nerve stimulation (tVNS) device
What this could lead to
If it works, this could point toward a non-drug treatment to reduce rapid heartbeat and other symptoms in people with POTS.
What could go wrong
This is a very small, early-stage trial with only 24 participants. The effect may be small or not work at all, and results may not apply to everyone with POTS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2025

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female patients aged ≥18 years * Diagnosis of POTS, defined as heart rate increase \>30 beats/min from supine within 10 minute of standing, in the absence of orthostatic hypotension (\>20/10 mm Hg fall in blood pressure), with chronic symptoms (\>6 months), and in the absence of other acute causes of orthostatic tachycardia, * Signed written informed consent by the patient for participation in the study and agreement to comply with the study procedures and the follow-up schedule. Exclusion Criteria: * Hypertension (\>150 mmHg systolic and \>100 mmHg diastolic) based on history or findings at screening. * Orthostatic hypotension (consistent drop in blood pressure \>20/10 mmHg with 10 min of standing) * History or presence of significant neurological, immunological, or hematological disorders * Cardiovascular disease, such as myocardial infarction within 6 months * Patients on renal dialysis. * Life expectancy of \<12 months * Currently pregnant women or women planning on becoming pregnant ≤ 5 months * Patients with active implants (such as a cardiac pacemaker, implantable cardioverter-defibrillator, or a cochlear implant) * Known channelopathy such as Brugada syndrome, long QT syndrome, or Catecholaminergic monomorphic ventricular tachycardia. * Episodic or permanent complete heart block or 2nd degree atrioventricular block Mobitz 2 or bifascicular block with concurrent 1st degree atrioventricular block * Congestive heart failure New York Heart Association class IV, defined as shortness of breath at rest, which is refractory to medical treatment (not responding to treatment) * Inability to comply with the protocol.

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Conditions

The condition(s) this trial relates to.

postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postural orthostatic tachycardia syndrome (POTS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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