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Could zapping the brain ease nerve pain in NMOSD?

NCT ID NCT07377305

Symptom relief Sponsor: Tang-Du Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a non-invasive brain stimulation device (tTIS) to see if it can safely reduce neuropathic pain in people with neuromyelitis optica spectrum disorder (NMOSD). Twelve participants will receive the stimulation and report their pain levels. The goal is to find a new, drug-free option for chronic nerve pain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial temporal interference stimulation (tTIS) device
What this could lead to
If it works, this could point toward a drug-free way to reduce chronic nerve pain in NMOSD patients.
What could go wrong
This is a very small, early pilot study with only 12 people and no placebo group, so results may not be reliable or apply to others.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with NMOSD in accordance with the criteria of the International Panel for Neuromyelitis Optica Diagnosis (IPND). * Patients were complicated with neuropathic pain, with a DN4 score ≥ 4. * NRS score for pain ≥ 4 points, and neuropathic pain has persisted for more than 3 months. * Patients receiving biological therapy and/or prednisone at a stable dose, with no adjustment of the treatment plan within 30 days before enrollment. * Patients who have not adjusted any combination of standard analgesic drugs (including antiepileptic drugs, antidepressants, and opioid drugs) within 30 days before enrollment. * Patients or their family members who have signed a written informed consent form. Exclusion Criteria: * Subjects participating in other clinical studies. * Subjects who have used investigational drugs for pain control within 30 days before enrollment. * Subjects with a concurrent diagnosis of peripheral neuropathy. * Subjects with concurrent active central nervous system diseases. * Subjects with cognitive or mental disorders. * Subjects who are pregnant, lactating, or planning to become pregnant during the study period. * Subjects with severe diseases related to the heart, liver, kidneys, or hematopoietic system. * Subjects with implanted devices in the body (such as cardiac pacemakers, nerve stimulators, etc.). * Subjects with a history of transcutaneous electrical nerve stimulation (TENS) allergy, latex allergy, or previous intolerance. * Subjects with contraindications to MRI examination. * Subjects with head skin lesions. * Other medical conditions or situations that the researcher deems may affect the achievement of the study objectives.

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Conditions

The condition(s) this trial relates to.

neuromyelitis optica

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nmo spectrum disorder

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Tangdu Hospital

    RECRUITING

    Xi'an, Shaanxi, 710038, China

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