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Could sound waves boost brain health in Alzheimer's?

NCT ID NCT07143734

Symptom relief Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a non-invasive device that sends low-energy pulses to the brain, aiming to improve thinking and behavior in people with early Alzheimer's. Forty adults aged 60-90 will receive either real or sham (fake) pulses over several weeks. Researchers will measure changes in memory, mood, and daily function to see if the treatment is safe and helpful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial pulse stimulation (TPS) device
What this could lead to
If it works, this could point toward a non-invasive, drug-free way to slow cognitive decline and reduce neuropsychiatric symptoms in early Alzheimer's disease.
What could go wrong
This is a very small pilot study (40 people) testing a new device approach. The effect may be small or no better than placebo, and long-term benefits or risks are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults who have been clinically diagnosed with Alzheimer's Disease in the early stage 2-6a according to the Functional Assessment Staging Test (In Appendix A) * The mental capacity to give informed consent for research is made by an experienced geriatrician based on Appendix A. * Aged 60-90 years old. * Able to make informed consent under assistance, which is witnessed and signed by a family caregiver. Exclusion Criteria: * Cannot understand Chinese. * Mentally incapacitated, unable to provide informed consent * Inability to remain still for 30 minutes * Lack of available family caregiver to answer questionnaires * Alcohol or substance dependence * Major neurological conditions, including: * Brain tumor * Brain aneurysm * Presence of any metal implants in the brain * Hemophilia or other blood clotting disorders * History of thrombosis

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer dementia (AD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese UNiversity of Hong Kong

    RECRUITING

    Hong Kong, Hong Kong

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