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Menthol vapors may replace eye drops for dry eyes

NCT ID NCT07109609

Symptom relief Sponsor: Reinhold Vieth Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether applying menthol solution to the cheek can release vapors that stimulate cold sensors on the eye, triggering natural tear production. Thirty healthy adults will receive either menthol or a placebo on one cheek, and researchers will measure if tears overflow within five minutes. If successful, this could lead to a new way to manage dry eyes without eye drops.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
menthol solution
What this could lead to
If it works, this could offer a simple, drug-free way to stimulate natural tears and reduce reliance on eye drops for dry eyes.
What could go wrong
This is a small early-phase trial in healthy people, not those with dry eyes. The effect may be weak or not work at all, and menthol may cause irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Not under care of an opthalmologist for treatment of dry-eyes Exclusion Criteria: * • Excluded if "Yes" to any of the questions below. * Are you allergic to menthol or to menthol-containing products like tooth paste or certain cold remedies? * Are you wearing contact lenses during the time of testing? \_\_\_\_\_\_\_\_ * Are there tears present prior to applying the menthol? \_\_\_\_\_\_\_\_ * Did you use of eye drops during the hour before participation? \_\_\_\_\_\_\_\_ * Do you have broken, irritated, sensitive skin and/or acne at or around application site? \_\_\_\_\_\_\_\_ * Do you have a history of atopy, allergic diseases at the skin of your cheeks? * Do you have Stevens-Johnson syndrome, which is any known skin response to chemical, thermal, or radiation injury to the application area? \_\_\_\_

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Conditions

The condition(s) this trial relates to.

corneal disorder dry eye syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dry eyes Healthy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Stearacl Incorporated.

    Toronto, Ontario, M4K1X4, Canada

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