Toothpaste showdown: new study pits three formulas against sensitive teeth
NCT ID NCT07664592
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 2 times
Summary
This Phase 3 trial compares three different toothpaste technologies for relieving tooth sensitivity (dentin hypersensitivity). About 132 adults with sensitive teeth will brush with one of three toothpastes: one with 8% arginine, one with 8% arginine plus zinc, or one with 5% calcium sodium phosphosilicate. Researchers will measure how well each paste reduces pain from air and touch stimuli right after brushing and over two weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- toothpaste containing 8% arginine, 8% arginine with zinc phosphate, or 5% calcium sodium phosphosilicate
- What this could lead to
- If successful, this study could show which toothpaste technology works best for quick and lasting relief from tooth sensitivity.
- What could go wrong
- This is a short-term trial (2 weeks) with only 132 participants, so results may not apply to everyone. Tooth sensitivity can have many causes, and these pastes may not work for all types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 132 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2026
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Sign an Informed Consent Form; 2. Male or female 18 to 70 years of age, inclusive; 3. Be in good general health as determined by the study investigators (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study. Examples include heart problems, valve/hip replacements, etc); 4. Willingness to provide information related to their medical history; 5. Available for the two (2) weeks duration of the study; 6. Minimum of 16 uncrowned permanent natural teeth (excluding third molars and crowns); 7. Must present at least two (2) sensitive teeth which must meet ALL of the following criteria: 1. Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion and/or gingival recession; 2. Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale. Exclusion Criteria: 1. Gross oral pathology, chronic disease, and/or history of allergies to any of the test products; 2. Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past month prior to start of the study; 3. Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months, dental cleaning it's permitted; 4. Sensitive teeth with a mobility greater than one; 5. Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures; 6. Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, daily use of analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study; to be defined by the dental examiner; or other drugs that could affect pain sensation; 7. Current smokers and subjects with a history of alcohol or drug abuse; 8. Participation in any other oral clinical study for the duration of this study; 9. Self-reported pregnancy and/or currently breastfeeding; 10. Allergies to oral care products, personal care consumer products, and/or their ingredients; 11. Medical condition which prohibits not eating/drinking for 4 hours. 12. Extended use of antibiotics or therapeutic mouthwash (eg: Chlorhexidine) any time during the three months prior to entry into the study; 13. Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine); 14. Current use of orthodontic appliances (including fixed braces, clear aligners, or permanent retainers)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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IEAPOM
RECRUITINGPorto Alegre, Rio Grande do Sul, 91530-001, Brazil
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