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Toothpaste showdown: can stannous fluoride beat sensitivity?
NCT ID NCT06244290
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 3 trial tested whether a toothpaste with stannous fluoride reduces tooth sensitivity better than a potassium-based toothpaste or regular fluoride toothpaste. 123 adults with sensitive teeth used one of the three toothpastes for 7 days. The study measured sensitivity to touch and air blasts to see which toothpaste worked best.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- stannous fluoride toothpaste
- What this could lead to
- If it works, this could offer a more effective option for people with sensitive teeth.
- What could go wrong
- This is a short-term study (7 days) with 123 participants, so results may not apply to long-term use or everyone. Tooth sensitivity can have many causes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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123 people
The number who actually took part.
- Started
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Sep 2020
- Finished
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Oct 2020
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Sign an Informed Consent Form; * Male or female 18 to 70 years of age, inclusive; * Be in good general health as determined by the study investigators; * Available for the seven (7) days duration of the study; * Must present two (2) sensitive teeth which must meet ALL of the following criteria: * Be anterior to the molars and demonstrating dentin exposure due to cervical erosion/abrasion and/or gingival recession; * Have a qualifying dentin hypersensitivity response to tactile stimuli applied to the cervical surface (gingivo-facial 1/3) as defined by a response score between 10- 50grams of force (Yeaple Probe, XiniX Research Inc. Portsmouth, NH, USA); * Have a qualifying dentin hypersensitivity response to air blast stimuli applied for one second to the cervical surface (gingivo-facial 1/3) as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale Exclusion Criteria: * Gross oral pathology, chronic disease, and/or history of allergies to any of the test products; * Use of a desensitizing oral care product and/or recipient of any dental desensitizing treatment within the past three months prior to start of the study; * Advanced periodontal disease and/or treatment for periodontal disease (including surgery) within the past twelve months; * Sensitive teeth with a mobility greater than one; * Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures; * Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily use of analgesics; * Participation in any other oral clinical study for the duration of this study * Self-reported pregnancy and/or currently breastfeeding; * Allergies to oral care products, personal care consumer products, and/or their ingredients; * Medical condition which prohibits not eating/drinking for 4 hours.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mesa Dental Centre
Costa Mesa, California, 92627, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.