Whitening showdown: 5% peroxide toothpaste takes on regular paste in One-Week trial
NCT ID NCT06957249
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 3 trial tested whether a Colgate toothpaste with 5% hydrogen peroxide and fluoride whitens teeth better than a toothpaste without hydrogen peroxide. Eighty adults brushed with one of the two toothpastes for one week. Researchers measured tooth color changes using a standard shade guide. The goal was to see if the peroxide toothpaste provides a noticeable whitening boost.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 5% hydrogen peroxide toothpaste
- What this could lead to
- If it works, this could confirm that a 5% hydrogen peroxide toothpaste whitens teeth more effectively than a non-whitening toothpaste.
- What could go wrong
- This is a short, small trial (80 people, one week) focused only on tooth shade, not long-term safety or durability. Results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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80 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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May 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Signed Informed Consent Form; * Male and female subjects 18-70 years old, inclusive; * Good general health and good oral health based on the opinion of the study investigator; * All maxillary natural permanent anterior teeth (6-11) must be present; * Availability for the duration of the study; * Minimum average Vita Extended Bleachedguide 3D-Master shade score of 17 ≥ or darker. Exclusion Criteria: * Presence of orthodontic appliances and/or any anterior tooth with a prosthetic crown, veneer, or deemed non-vital; * Obvious signs of periodontal disease, rampant caries, or any condition that the dental examiner considers exclusionary from the study; * Five or more carious lesions requiring immediate care; * Concurrent participation in another clinical study; * Self-reported pregnant and/or lactating women; * History of allergies or sensitivity to tooth whitening products, hydrogen peroxide, personal care consumer products, or their ingredients; * Restorations on the teeth to be scored which may interfere with scoring procedures; * Have used a professional whitening product within one (1) year and/or had a dental prophylaxis (professional dental cleaning) within thirty (30) days prior to the start of the study
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Consumer Research Consulting, LLC
Melbourne, Florida, 32940, United States
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