New toothpaste aims to zap tooth pain fast
NCT ID NCT06960148
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a special toothpaste with 8% arginine (CSPR) can reduce tooth sensitivity better than a regular Colgate toothpaste. 95 adults with sensitive teeth used the toothpaste for 8 weeks. Researchers measured sensitivity using a gentle touch test and a cold air blast. The goal was to see if the arginine toothpaste provides faster and longer-lasting relief.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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95 people
The number who actually took part.
- Started
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Mar 2025
- Finished
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May 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male and female subjects, ages 18-70, inclusive. * Availability for the eight-week duration of the study. * Two sensitive teeth, which must be anterior to the molars, and demonstrate cervical erosion/abrasion or gingival recession. * Qualifying response to tactile stimuli (Yeaple probe) as defined by a score between 10-50 gms. of force. * Qualifying response to the air blast stimuli as defined by a score of 2 or 3 on the Schiff Cold Air Sensitivity Scale. * Subjects need to satisfy the qualifying response to stimuli for both the parameters assessed (tactile or air) on two teeth to be entered into the study. * Good general health with no known allergies to products being tested. * Use of a non-desensitizing dentifrice for three months prior to entry into the study. * Signed Informed Consent Form. Exclusion Criteria: * Gross oral pathology, chronic disease, or history of allergy to test products. 2. Advanced periodontal disease or treatment for periodontal disease (including surgery) within the past twelve months. * Sensitive teeth with a mobility greater than one. * Teeth with extensive/defective restorations (including prosthetic crowns), suspected pulpitis, caries, cracked enamel, or used as abutments for removable partial dentures. * Current use of anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory drugs, or daily use of analgesics. * Participation in a desensitizing dentifrice study or regular use of a desensitizing dentifrice within the past three months. * Current participation in any other clinical study. * Pregnant or lactating subjects. * Allergies to oral care products, personal care consumer products, or their ingredients. * Medical condition which prohibits not eating/drinking for 4 hours.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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West China Dental Institute of Chengdu
Chengdu, Sichuan, 610041, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.