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New gel may ease tooth sensitivity during whitening treatments

NCT ID NCT07355647

Symptom relief Sponsor: University of Santiago de Compostela Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a desensitizing gel called UltraEZ can reduce tooth sensitivity during in-office bleaching. Thirty healthy adults with dark teeth received either UltraEZ or a placebo before bleaching. Researchers measured pain levels and color change to see if the gel helped without affecting whitening results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
UltraEZ (a desensitizing agent)
What this could lead to
If effective, UltraEZ could make tooth bleaching more comfortable by reducing sensitivity without compromising whitening.
What could go wrong
This is a very small early-phase trial with only 30 participants, so results may not apply to everyone. The desensitizing agent might not reduce sensitivity as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

30 people

The number who actually took part.

Started

May 2025

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * No oral os systemic pathology * Periodontally Healthy * No cavities * Tooth shade of the canines A2 or darker Exclusion Criteria: * Adhesive restorations or protheses in the anterior region * Enamel or dentin alterations * Smoking habits * Pregnant women * Undergone prior bleaching treatment

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Conditions

The condition(s) this trial relates to.

dentin sensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sensitivity, tooth

Contacts and locations

Locations

  • School of Medicine and Dentistry

    Santiago de Compostela, A Coruña, 15705, Spain

More trials for these conditions

Other studies related to the condition(s) this trial covers.