Can a toothpaste stop the ouch in teeth whitening?
NCT ID NCT06608368
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a toothpaste with NovaMin (Sensodyne Repair and Protect) can reduce tooth sensitivity during and after teeth bleaching. 90 adults used either the test toothpaste, a standard fluoride toothpaste, or another sensitivity toothpaste. Participants rated their sensitivity daily. The goal was to see if the test toothpaste works better than the others for comfort during whitening.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Sensodyne Repair and Protect toothpaste (contains NovaMin and fluoride)
- What this could lead to
- If it works, this could point toward a more effective toothpaste for people who get tooth sensitivity during whitening treatments.
- What could go wrong
- This is a small, completed Phase 4 study. Results may not apply to everyone, and the effect may be modest. Tooth sensitivity varies a lot between people.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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90 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Nov 2024
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participant provision of a signed and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the study before any assessment is performed. * Participant is of either sex and any gender who, at the time of screening, is between the ages of 18-65 years, inclusive. * Participant is willing and able to comply with scheduled visits, and other study procedures and restrictions. * Participant in good general and mental health with, in the opinion of the investigator or medically qualified designee, no clinically significant or relevant abnormalities in medical history (for example, a medical condition confirmed to be causing xerostomia), or upon oral examination, that would impact the participant's safety, wellbeing or the outcomes of the study, if they were to participate in the study, or affect the participant's ability to understand and follow study procedures and requirements. * Participant who wishes and is able to undergo at-home peroxide tooth bleaching. * Participant with generally good oral health that fulfil all of the following: 1. Having no lesions of the teeth or oral cavity that could interfere with the study evaluations. 2. At least a total of 11 of the facial surfaces of maxillary and mandibular anterior 6 teeth (tooth numbers 6-11 and 22-27) suitable for peroxide whitening and gradable for VITA Bleachedguide evaluation with no significant defects, calculus, restorations, crowns or veneers that could impact tooth bleaching performance or study evaluations as judged by the clinical examiner. 3. A minimum of 16 natural teeth. Exclusion Criteria: * Participant who is an employee of the investigational site, either directly involved in the conduct of the study or a member of their immediate family; or an employee of the investigational site otherwise supervised by the investigator; or, a Haleon employee directly involved in the conduct of the study or a member of their immediate family. * Participant who has participated in other studies (including non-medicinal studies) involving investigational product(s) within 60 days prior to study entry and/or during study participation. * Participant with, in the opinion of the investigator or medically qualified designee, an acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator or medically qualified designee, would make the participant inappropriate for entry into this study. * Participant who is pregnant or intending to become pregnant over the duration of the study or who is breastfeeding. * Participant with known or suspected intolerance or hypersensitivity to the study materials \[including the peroxide whitening gel\] (or closely related compounds) or any of their stated ingredients. * Participant who, in the opinion of the investigator or medically qualified designee, has a condition that would impact on their safety or wellbeing or affect their ability to understand and follow study procedures and requirements or who should not participate in the study for other reasons. * Participant unwilling or unable to comply with the Lifestyle Considerations described in this protocol. * Participant with a recent history (within the last year) of alcohol or other substance abuse. * Participant with gross periodontal disease or who has had treatment for periodontal disease (including surgery) within 12 months of Screening or who has had scaling or root planning within 3 months of Screening. * Participant who has had a tooth bleaching procedure (either professionally dispensed or at home) within 12 months of Screening. * Participant with a fixed or removable partial prosthesis, multiple dental implants or orthodontic braces/bands or fixed retainer or togue/lip piercing which, in the opinion of the investigator, could impact study outcomes. * During the period from screening till 2 weeks post completion of tooth bleaching, participant taking daily doses of medication/treatments which, in the opinion of the investigator or medically qualified designee, could interfere with their perception of tooth sensitivity (examples of such medications include analgesics, anticonvulsants, antihistamines that cause marked or moderate sedation, sedatives, tranquilizers, antidepressants, mood-altering and anti-inflammatory drugs). * Participant who has previously been enrolled in this study. * Participant who has used an oral care product indicated for the relief of DH or care of sensitive teeth within 8 weeks of Screening (participants will be required to verbally confirm the name of their current oral care products to enable site staff to verify the absence of known sensitivity ingredients). * Participant who is taking daily doses of a medication which, in the opinion of the investigator or medically qualified designee, is causing xerostomia. * Participant who has had dental prophylaxis within 4 weeks of Screening or who requires antibiotic prophylaxis for dental procedures.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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All Sum Research
Mississauga, Ontario, L5N 6J2, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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