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Can tongue presses keep ALS patients swallowing? small trial aims to find out

NCT ID NCT07295990

Symptom relief Sponsor: Nova Southeastern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 3 times

Summary

This study tests a five-week tongue exercise program for 20 people with ALS to see if it can help with swallowing and speech. Participants press their tongue against a device at home five days a week, with weekly check-ins via telehealth. Researchers will measure tongue strength and swallowing safety before and after the program.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Isometric lingual strength exercises (tongue press exercises)
What this could lead to
If it works, this could point toward a simple, at-home exercise program to help maintain swallowing and speech in people with ALS.
What could go wrong
This is a very small, early study with only 20 participants and no comparison group. The exercises may not slow disease progression or provide lasting benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of possible, probable, or definite ALS (El-Escorial Revisited) * Lingual exercises naïve * Impaired lingual strength generation compared to normative data * EAT-10 score \<3 Exclusion Criteria: * Stroke * Head injury * Head and neck cancer * Tracheostomy * Other concomitant neurogenic disorder * Recent oral surgery other than routine dental surgery * Unable to generate isometric lingual pressure on lingual manometer * Participation in another clinical trial intervention that may confound results * NPO (nothing by mouth) * Anarthric

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis Deglutition Disorders Dysarthria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS (amyotrophic lateral sclerosis)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nova Southeastern University

    RECRUITING

    Davie, Florida, 33314, United States

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