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New MRI study aims to better understand jaw joint disease

NCT ID NCT07008690

Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses MRI scans to track changes in the jaw joint over 18 months in people with degenerative joint disease. Researchers will compare these scans to those from healthy volunteers to learn more about how the disease progresses. No drugs or contrast agents are used. The goal is to gather information that could help design future studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with DJD will be recruited during routine examinations at the TMD clinic located at the School of Dentistry, UMN. If eligible and interested, participants will undergo approximately 90 minutes of qMRI scans. Additional follow-up scans may occur over 18 months, while control participants will have two scans 1-4 weeks apart.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. To participate in this study, patients (with DJD) must: * Be 18 years or older * Provide written informed consent in English * State willingness to comply with all study procedures and be available for the duration of the study * Have clinically confirmed DJD diagnoses based on CT and/or radiographs, and /or traditional MRI scan obtained by their clinician. * Willing to have a separate approximately 2-hour appointment to have an MRI at the CMRR * Has the ability to manage their own calendar and schedule appointments * Does not have a serious medical condition * Is not pregnant or is not potentially pregnant 2. To participate in this study, controls (participants without DJD) must: * Be 18 years or older * Provide written informed consent in English * State willingness to comply with all study procedures and be available for the duration of the study * Confirm the absence of any pre-existing TMJ disease * Willing to have a separate approximately 2-hour appointment to have an MRI at the CMRR * Has the ability to manage their own calendar and schedule appointments * Does not have a serious medical condition * Is not pregnant or is not potentially pregnant 3. Exclusion Criteria: Participants will be excluded if they: * Contraindications to MRI. Exclusion criteria for MRI are: 1. Ferromagnetic implants 2. History of shrapnel or shot gun injury 3. Too large to fit in the magnet (body mass index \>= 40, approx.) 4. Cardiac pacemakers 5. Severe claustrophobia 6. Large tattoos 7. History of metalwork * Are non-English speaking * Could be pregnant

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Conditions

The condition(s) this trial relates to.

arthropathy disease osteoarthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Control subjects Degenerative joint disease

Contacts and locations

Locations

  • Orofacial MRI Center at UMN

    Minneapolis, Minnesota, 55455, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.