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New combo treatment aims to quiet jaw pain for TMD sufferers

NCT ID NCT07401745

Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether wearing a custom mouth splint and getting a granisetron injection into the jaw muscle reduces pain from temporomandibular disorders (TMD) better than the splint alone or with lidocaine. About 48 adults with jaw muscle pain will be followed for 6 months. The goal is to find a more effective way to ease pain and improve jaw movement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

48 people

The number who actually took part.

Started

Jan 2026

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 19 - 45 years. * Diagnosis of myofascial pain according to the Research Diagnostic Criteria for TMD Axis I (RDC/TMD). * Pain upon digital palpation of the masseter and/or the temporalis muscles. * Patients with disc displacement with or without reduction in any of the TMJs. * Co-operative patients. Exclusion Criteria: * Diagnosed systemic muscular or joint diseases (e.g. fibromyalgia, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis). * Whiplash-associated disorder. * Neuropathic pain or neurological disorders (e.g. myasthenia gravis, orofacial dystonia). * History of psychiatric disorders. * Pain of dental origin. * Use of muscle relaxants or other medication that might influence the response to pain. * Pregnancy or lactation. * Known hypersensitivity to granisetron or lidocaine

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Conditions

The condition(s) this trial relates to.

Facial Pain myofascial pain syndrome temporomandibular joint disorder temporomandibular joint dysfunction syndrome transient myeloproliferative syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Temporomandibular disorder (TMD) TMD TMD/orofacial pain

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University

    Al Mansurah, Dakahlia Governorate, 35511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.