Electric zap to the ear may quiet ringing
NCT ID NCT03759834
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether a brief electrical stimulation of the inner ear could temporarily reduce tinnitus (ringing in the ears) in 25 adults with severe, disruptive tinnitus. Researchers aimed to find the best spot for stimulation to guide development of a future implantable device for long-term relief. The main goal was to measure changes in tinnitus severity using a standard questionnaire.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Cochlear promontory stimulation (electrical stimulation device)
- What this could lead to
- If successful, this could lead to an implantable device that provides long-term relief for chronic tinnitus sufferers.
- What could go wrong
- This was a small, early-stage study (25 participants) focused on short-term effects, so results may not apply to everyone or lead to a permanent solution. Risks include discomfort or no benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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25 people
The number who actually took part.
- Started
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Jan 2018
- Finished
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Aug 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Normal to moderate sensorineural hearing loss (based on pure tone audiometry (PTA) of 500, 1000 and 2000 Hz) and a word recognition score equal to or greater than 60% 2. Asymmetric or unilateral subjective tonal tinnitus 3. Tinnitus that is disruptive 1. Determined by THI score (in the severe range i.e. ≥56/100) 2. TFI (in the severe range i.e. ≥52/100) 3. Tinnitus VAS (≥ 5/10 ) 4. Tinnitus that is intractable, and has not been ameliorated by conventional measures such as a hearing aid or masking 5. Normal contrast-enhanced MRI of the head Exclusion Criteria: 1. Tinnitus present less than 6 months or longer than 12 years; it is permissible to include people who have had intermittent or constant tinnitus longer than 12 years as long as it was not perceived as severe longer than 12 years 2. History of brain or major ear surgery 3. Prior major head trauma 4. Ongoing clinical diagnosis of depression or anxiety; for the purposes of this study, it is permissible to include people who: 1. have a past history of clinically diagnosed depression or anxiety that is no longer currently active; or 2. people who have depressive or anxious symptoms that are thought to primarily result from severe tinnitus a. Determined by screening using the GAD 7, PHQ8, and HAI-S * GAD7 \> 9 (indicates clinically significant anxiety) * PHQ \> 9 (indicates clinically significant depression) * HAI-S \> 25 (hypochondriacal level illness anxiety) 5. Inability to assess, continue or complete trial 6. Currently on regularly scheduled antidepressants, anxiolytics or antipsychotics; for this study, it is permissible to include people who use such medications at lower doses as a sleep aid or for people who intermittently use such medications for situational anxiety (e.g., Ativan before airplane travel) 7. Active use of other tinnitus treatments; for the purposes of this study it is permissible to include people who prefer to use a hearing aid to amplify ipsilateral hearing loss 8. Known pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Other studies related to the condition(s) this trial covers.
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