Feeding delay after esophageal surgery studied for muscle preservation
NCT ID NCT03676478
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study aimed to see if delaying feeding for a few days after esophageal cancer surgery helps protect muscle mass and improve recovery. It included 239 adults with esophageal cancer who were scheduled for surgery. The study was stopped early, so results are limited.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
239 people
The number who actually took part.
- Started
-
Mar 2019
- Finished
-
Dec 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 90 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Candidates for surgical resection with a curative intent, admitted to our Department. * Able to understand the study information in Dutch or French and tasks related to the study measurements provided by the researchers. * Able to consent. * Patients with cancer of the gastroesophageal junction (GEJ), distal, mid- and proximal thoracic esophagus. * Patients with early as well as advanced clinical stage esophageal cancer: from clinical stages cT1N0 over cT2+ N+ or cT3 Nx after neo-adjuvant therapy or at the time of staging as a candidate for primary surgery. * Histology preop: Squamous or adenocarcinoma. * Patients must undergo at least two-field lymphadenectomy; three-field lymphadenectomy if deemed necessary by the clinical team is not a contraindication for inclusion. * All access: (robotic assisted) minimal invasive (thoracoscopy \& laparoscopy) approach, left thoraco-abdominal incision, hybrid esophageal resection or R thoracotomy + laparotomy * Partial or subtotal esophagectomy. * Reconstruction by gastric conduit. * All anastomoses (intrathoracic or cervical). * Women of child bearing age with esophageal cancer can be included. Exclusion Criteria: * Patients in a definitive chemoradiation protocol, or undergoing rescue resection following definitive chemoradiotherapy. * Patients expected to die within 12 hours (=moribund patients). * Patients transferred from another institute after esophageal resection with an established nutritional therapy. * Patients with a cT4b tumor after neo-adjuvant therapy. * Patients who are at the time of surgery deemed unresectable or found to be unresectable during surgery. * Patients with a R2-resection. * Patients with metastasis at the time of clinical staging. * Patients undergoing transhiatal resection of the esophagus. * Patients undergoing total gastrectomy * Patients undergoing an esophageal resection or esophageal bypass as palliative treatment * Patients with tumors in the cervical esophagus with a distance less than 3cm from the cricopharyngeal sphincter. * Patients with pharyngeal cancer undergoing (laryngo-)pharyngectomy with gastric pull-up * Need for colonic or jejunal interposition * Patients with a second synchronous malignancy * Patients with inflammatory bowel disease (as this might interfere with caloric uptake in the small bowel) * Patients with contra-indications for enteral nutrition. * Patients already participating in a study with a nutritional intervention.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Esophageal cancer are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University Hospitals Leuven, dept. of Thoracic Surgery
Leuven, 3000, Belgium
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood proteins may predict who beats esophageal cancer with chemoradiation
- Can timing of spine surgery predict how well arm weakness recovers?
- New Antibody-Drug conjugate put to the test against Hard-to-Treat cancers
- A standard IV fluid dose may reveal who is at risk after bowel surgery
- Can video games and pilates rebuild strength after severe burns?
- Can a direct hit to tumors make immunotherapy work better?