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New study tracks Tick-Borne brain infection recovery to improve patient care

NCT ID NCT07274046

Knowledge-focused Sponsor: Charles University, Czech Republic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 209 children and adults hospitalized with tick-borne encephalitis (TBE) in the Czech Republic for one year after discharge. Researchers track symptoms like fatigue, headaches, memory problems, and weakness to see how long they last and who needs extra support. The goal is to better understand recovery and help guide vaccination and public health decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could improve follow-up care for TBE patients and support vaccination policies to prevent long-term health problems.
What could go wrong
This is an observational study, not a treatment trial, so it won't test any new therapy. Results may not apply outside the Czech Republic.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 209 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Hospitalized children and adults with confirmed tick-borne encephalitis (TBE) treated at four infectious disease centers in the Czech Republic. All participants had clinical symptoms of central nervous system involvement, cerebrospinal fluid pleocytosis, and laboratory confirmation of TBEV infection. Patients were enrolled during their acute hospitalization and followed prospectively for up to 12 months as part of a standardized clinical and functional outcome assessment program.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Hospitalization due to suspected central nervous system (CNS) infection. * Laboratory-confirmed TBE, defined as: the presence of CNS symptoms and cerebrospinal fluid pleocytosis (\>5 × 10⁶/L) and TBEV IgM and IgG seropositivity in serum, or detection of TBEV IgM in CSF in previously vaccinated individuals. * All age groups (children and adults). * Ability to participate in scheduled follow-up (in person or via telephone). * Informed consent provided by the patient or legal guardian (for minors). Exclusion Criteria: * Alternative diagnosis explaining the CNS symptoms * Missing essential clinical or laboratory data required to confirm TBE or assess outcomes. * Refusal or inability to provide informed consent. * Inability to complete follow-up assessments, including situations where reliable contact cannot be maintained. * Coexisting severe neurological disorder unrelated to TBE that prevents meaningful evaluation of sequelae (e.g., advanced neurodegenerative disease, severe preexisting motor disability).

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Conditions

The condition(s) this trial relates to.

encephalitis tick-borne encephalitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tick-borne encephalitis (TBE)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bulovka University Hospital

    RECRUITING

    Prague, Prague, 18081, Czechia

  • Ostrava University Hospital

    RECRUITING

    Ostrava, Moravian-Silesian Region, 70800, Czechia

  • Pardubická nemocnice

    RECRUITING

    Pardubice, Pardubice Region, 53001, Czechia

  • České Budějovice Hospital

    RECRUITING

    České Budějovice, South Bohemian Region, 37001, Czechia

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