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Skipping thyroid ultrasound after PET may be safe, study suggests

NCT ID NCT07255482

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This study examines whether patients who have a thyroid nodule found on a PET scan can safely skip a follow-up ultrasound without affecting their survival. Researchers will compare death rates over 7 years between those who had an ultrasound within 3 months and those who did not. The study uses medical records from 5,000 adults in the Mass General Brigham health system. If skipping ultrasound proves non-inferior, it could reduce unnecessary procedures and patient anxiety.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Thyroid ultrasound
What this could lead to
If this study shows that skipping ultrasound does not increase death risk, it could reduce unnecessary procedures and anxiety for many patients.
What could go wrong
This is an observational study using existing medical records, not a controlled trial. Results may be influenced by other factors and cannot prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

874 people

The number who actually took part.

Started

Oct 2025

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who had a PET-CT at Mass General Brigham 1/1/2015 to 12/31/2021

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age \>=18 2. Thyroid nodule on PET-CT performed 1/1/2015 to 12/31/2021 3. At least one clinical note in the EHR from the 36-month window prior to the PET Exclusion Criteria: 1. Thyroid ultrasound listed in the medical record in the prior 3 years 2. Documented history of prior thyroid cancer diagnosis

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.