Skipping thyroid ultrasound after PET may be safe, study suggests
NCT ID NCT07255482
First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 3 times
Summary
This study examines whether patients who have a thyroid nodule found on a PET scan can safely skip a follow-up ultrasound without affecting their survival. Researchers will compare death rates over 7 years between those who had an ultrasound within 3 months and those who did not. The study uses medical records from 5,000 adults in the Mass General Brigham health system. If skipping ultrasound proves non-inferior, it could reduce unnecessary procedures and patient anxiety.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Thyroid ultrasound
- What this could lead to
- If this study shows that skipping ultrasound does not increase death risk, it could reduce unnecessary procedures and anxiety for many patients.
- What could go wrong
- This is an observational study using existing medical records, not a controlled trial. Results may be influenced by other factors and cannot prove cause and effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
874 people
The number who actually took part.
- Started
-
Oct 2025
- Finished
-
Aug 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients who had a PET-CT at Mass General Brigham 1/1/2015 to 12/31/2021
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age \>=18 2. Thyroid nodule on PET-CT performed 1/1/2015 to 12/31/2021 3. At least one clinical note in the EHR from the 36-month window prior to the PET Exclusion Criteria: 1. Thyroid ultrasound listed in the medical record in the prior 3 years 2. Documented history of prior thyroid cancer diagnosis
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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