Could cannabis compounds help tame opioid cravings and pain?
NCT ID NCT06544291
First seen Nov 16, 2025 · Last updated Jun 23, 2026 · Updated 30 times
Summary
This phase 2 study at Yale is testing whether a combination of THC and CBD can reduce both pain and opioid cravings in people who have opioid use disorder and chronic pain. The 147 participants are all on methadone therapy. Researchers will measure pain sensitivity and craving responses after a single dose of the cannabinoids.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Connecticut Mental Health Center
RECRUITINGNew Haven, Connecticut, 06519, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
THC and CBD (cannabinoids)
What this could lead to
If it works, this could point toward a new treatment that helps people with opioid addiction and chronic pain manage both conditions at once.
What could go wrong
This is an early phase 2 trial with only 147 participants, so results may not apply widely. The combination may cause side effects like dizziness or cognitive issues, and it's not yet proven to be effective.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.