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New Clot-Buster shows promise for Tough-to-Treat strokes

NCT ID NCT06196320

Disease control Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested a drug called tenecteplase in 452 people with a severe type of stroke caused by a blockage in the basilar artery at the back of the brain. Participants received either tenecteplase or the current best treatment (which could include another clot-buster or standard care) within 24 hours of symptoms. The main goal was to see if tenecteplase helps more people recover with little or no disability after 3 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Tenecteplase (a clot-busting drug given intravenously)
What this could lead to
If successful, this could provide a more effective and convenient treatment for severe strokes in the back of the brain, potentially reducing long-term disability.
What could go wrong
This is a completed phase 3 trial, but results are not yet published. The drug may not prove superior to current best practice, and there is a risk of bleeding, a known side effect of clot-busting drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

452 people

The number who actually took part.

Started

Jan 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18. 2. Patients presenting with posterior circulation ischemic stroke symptoms due to near-complete or complete basilar artery occlusion within 24 hours from symptom onset (or clinical deterioration/coma) or the time the patient was last known to be well. 3. Presence of a basilar artery occlusion, proven by CT Angiography or MR Angiography. Basilar artery occlusion will be defined as 'potentially retrievable' occlusion at the basilar artery. This can be a near or complete occlusion. 4. Premorbid mRS ≤3 (independent function or requiring only minor domestic assistance and able to manage alone for at least 1 week). 5. Local legal requirements for consent have been satisfied. Exclusion Criteria: 1. Intracerebral haemorrhage (ICH) or other diagnosis (e.g. tumour) identified by baseline imaging. 2. Posterior circulation Acute Stroke Prognosis Early CT Score (PC-ASPECTS) \<6 on non-contrast CT (NCCT) or CTA-source images or MRI diffusion weighted imaging (DWI). 3. Significant cerebellar mass effect or acute hydrocephalus. 4. Established frank hypodensity on non-contrast CT indicating subacute infarction. 5. Bilateral extensive brainstem ischemia. 6. Pre-stroke mRS of ≥4 (indicating moderate to severe previous disability). 7. Other standard contraindications to intravenous thrombolysis. 8. Contraindication to imaging with contrast agents. 9. Clinically evident pregnant women. 10. Vessel imaging showing both anterior and posterior circulation large vessel occlusion. 11. Current participation in another research drug treatment protocol. 12. Known terminal illness such that the patients would not be expected to survive a year. 13. Planned withdrawal of care or comfort care measures. 14. Any condition that, in the judgment of the investigator could impose hazards to the patient if study therapy is initiated or affect the participation of the patient in the study.

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Conditions

The condition(s) this trial relates to.

basilar artery occlusion ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic stroke, acute

Contacts and locations

Locations

  • Affiliated Hospital of Hebei University

    Baoding, Hebei, China

  • Beijing Daxing District People's Hospital

    Beijing, China

  • Beijing Tian Tan Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100070, China

  • Chenzhou First People's Hospital

    Chenzhou, Hunan, China

  • First People's Hospital of Tianshui

    Tianshui, Gansu, China

  • Gaomi People's Hospital

    Gaomi, Shandong, China

  • Guangdong Second Provincial General Hospital

    Guangzhou, Guangdong, China

  • Guangshan County People's Hospital

    Xinyang, Henan, China

  • Haikou People's Hospital

    Haikou, Hainan, China

  • Hengyang Central Hospital

    Hengyang, Hunan, China

  • Heyuan People's Hospital

    Heyuan, Guangdong, China

  • Hongxinglong Hospital of Beidahuang Group

    Shuangyashan, Heilongjiang, China

  • Huaxian People's Hospital of Henan

    Anyang, Henan, China

  • Huazhou People's Hospital

    Huazhou, Guangdong, China

  • Jiaozuo Coal Industry Central Hospital

    Jiaozuo, Henan, China

  • Jilin Electric Power Hospital

    Changchun, Jilin, China

  • Jiujiang First People's Hospital

    Jiujiang, Jiangxi, China

  • Keshketeng Banner Chinese-Mongolian Hospital

    Keshketeng Banner, Inner Mongolia, China

  • Laizhou City People's Hospital

    Laizhou, Shandong, China

  • Linfen Central Hospital

    Linfen, Shanxi, China

  • Linyi People's Hospital

    Linyi, Shandong, China

  • Liuhe County People's Hospital

    Tonghua, Jilin, China

  • Liuyang Jili Hospital

    Liuyang, Henan, China

  • Lixin County People's Hospital

    Haozhou, Anhui, China

  • Nanle County People's Hospital

    Puyang, Henan, China

  • Nanle Zhongxing Hospital

    Puyang, Henan, China

  • Nanshi Hospital of Nanyang

    Nanyang, Henan, China

  • Ningbo Beilun District People's Hospital

    Ningbo, Zhejiang, China

  • People's Hospital of Queshan

    Zhumadian, Henan, China

  • Puyang Oilfield General Hospital

    Puyang, Henan, China

  • Qiandongnanzhou People's Hospital

    Qiandongnan, Guizhou, China

  • Qingdao Municipal Hospital

    Qingdao, Shandong, China

  • Qinghe County People's Hospital

    Xingtai, Hebei, China

  • Qiu County People's Hospital

    Handan, Hebei, China

  • Shaoguan Qujiang District People's Hospital

    Shaoguan, Guangdong, China

  • Siping City Central People's Hospital

    Siping, Jilin, China

  • Taihe County Traditional Chinese Medicine Hospital

    Fuyang, Anhui, China

  • Taikang Xian People's Hospital

    Zhoukou, Henan, China

  • Tangshan Guye Traditional Chinese Medicine Hospital

    Tangshan, Hebei, China

  • The 2nd Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, China

  • The Affiliated Hospital of Shandong Second Medical University

    Weifang, Shandong, China

  • The First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, China

  • The First Affiliated Hospital of Jinzhou Medical University

    Jinzhou, Liaoning, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, China

  • The First People Hospital of Lingbao

    Lingbao, Henan, China

  • The Fourth People's Hospital of Chenzhou

    Chenzhou, Hunan, China

  • The People's Hospital of Liaoning Province

    Shenyang, Liaoning, China

  • The Second Affiliated Hospital of Guizhou Medical University

    Guiyang, Guizhou, China

  • The Second Affiliated Hospital of Shandong First Medical University

    Taian, Shandong, China

  • The Second Hospital of Qinhuangdao

    Qinhuangdao, Hebei, China

  • The Second People's Hospital of Dongying

    Dongying, Shandong, China

  • The Second People's Hospital of Guiyang

    Guiyang, Guizhou, China

  • Tongliao People's Hospital

    Tongliao, Inner Mongolia, China

  • Weifang People's Hospital

    Weifang, Shandong, China

  • Weihai Central Hospital

    Weihai, Shandong, China

  • Xi County People's Hospital

    Xinyang, Henan, China

  • Yantai Taochun Central Hospital

    Yantai, Shandong, China

  • Zaozhuang Municipal Hospital

    Zaozhuang, Shandong, China

  • Zhumadian Traditional Chinese Medicine Hospital

    Zhumadian, Henan, China

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Other studies related to the condition(s) this trial covers.