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Which ear zap feels best? scientists test two waveforms for vagus nerve stimulation

NCT ID NCT06614933

Knowledge-focused Sponsor: University of Miami Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested how different electrical waveforms (biphasic vs. monophasic) affect comfort and tolerability of transcutaneous auricular vagus nerve stimulation (taVNS) in 30 healthy adults. Participants received one hour of stimulation while reporting discomfort and heart rate changes. The goal is to identify the most tolerable waveform for future therapeutic applications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous auricular vagus nerve stimulation (taVNS) device
What this could lead to
If successful, this could help design more comfortable taVNS protocols for future therapeutic use.
What could go wrong
This is a small, early-stage study in healthy volunteers, so results may not apply to patient populations or predict long-term tolerability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Dec 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. between the ages of 18-80 years 2. English speaking (must be able to consent and complete the interviews in English) Exclusion Criteria: 1. chronic pain (average intensity \>2/10 on 0-10 scale, for longer than 3 months) 2. acute pain of intensity greater than 3/10 3. chronic inflammatory conditions that are poorly controlled (e.g., diabetes, autoimmune disease) 4. any unstable medical condition or medical contraindication to moderate physical exertion (e.g., unstable angina or cardiac arrythmia) 5. pregnancy 6. currently taking Buprenorphine or recently stopped taking (within 1 month) 7. presence of cognitive impairment or language barrier that impairs full autonomy in the consent process or in the ability to participate in detailed interviews 8. implants in the head or neck, cochlear implants, or pacemaker 9. head or neck metastasis or recent ear trauma 10. history of epilepsy 11. history of autonomic nervous system dysfunction (e.g., postural orthostatic tachycardia syndrome).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • University of Miami, Plumer Building

    Coral Gables, Florida, 33146, United States

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