Ear zap might ease pelvic pain in men
NCT ID NCT06287970
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a small device that gently stimulates a nerve in the ear can reduce pain and urinary symptoms in men with moderate to severe chronic prostatitis/pelvic pain syndrome. 68 participants will be randomly assigned to receive either real stimulation or a sham (inactive) version for 4 weeks, then followed for 8 more weeks. The goal is to see if this safe, non-invasive approach can improve quality of life without drugs.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcutaneous auricular vagus nerve stimulation (taVNS) device
- What this could lead to
- If it works, this could offer a non-drug, low-risk option to reduce pain and urinary symptoms in men with chronic prostatitis.
- What could go wrong
- This is a small, early-stage trial (68 people) testing a device against a sham. The effect may be small or no better than placebo, and long-term benefits are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 68 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2024
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Consistent with the diagnostic criteria of CP/CPPS of EAU or CAU, the clinical manifestations were recurrent and persistent prostate pain accompanied by abnormal urination and psychiatric symptoms, without infection or other obvious pathological conditions. The pain symptoms were mainly manifested as pain in the surrounding tissues centered on the prostate, and pain, swelling or discomfort in the scrotum, testis, lower abdomen, perineum, lumbosacral area, and medial thigh. Abnormal urination was characterized by frequent urination, urgent urination, urination pain, urethral burning, residual urination or white discharge from the urethra at the end of urination or defecation in the morning. The neuropsychiatric symptoms included dizziness and tinnitus, insomnia and dreams, anxiety and depression, and even impotence, premature ejaculation, and spermatorrhea. Symptoms lasting more than 3 months in the last six months * 18 ≤ Age ≤ 50 years old * NIH-CPSI ≥15 (patients with moderate to severe CP/CPPS) * Signed informed consent and voluntarily participated in the trial Exclusion Criteria: * Patients with other diseases that cause urinary symptoms were excluded: Such as benign prostatic hyperplasia, testicular and epididymal and spermatic cord diseases, overactive bladder, neurogenic bladder, interstitial cystitis, glandular cystitis, sexually transmitted diseases, bladder tumors such as carcinoma in situ, prostate cancer, urinary male reproductive system tuberculosis, anorectal diseases, lumbar diseases, central and peripheral neuropathy, etc * Patients with severe diseases of the heart, liver, kidney, hematopoietic system and poor nutritional status * Patients with severe mental and emotional disorders, who were unable to cooperate with the study * Patients who have been treated with CP/CPPS regimen in the past 4 weeks
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Guang'anmen Hospita, China Academy of Chinese Medical Sciences
RECRUITINGBeijing, Beijing Municipality, 100053, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Spa treatment shows promise for chronic kidney and urinary conditions
- Bladder pain breakthrough? study matches therapy to patient type
- Four sessions at home may tame pelvic pain without pills
- Shockwaves vs. sham: new hope for ED and pelvic pain?