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A scan that sees Alzheimer's tangles? trial puts tau tracer to the test

NCT ID NCT07752784

Diagnosis Sponsor: JYAMS PET Research & Development Limited Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 18, 2026 · Updated 4 times

Summary

This trial tests whether a single injection of [18F]-APN-1607, a radioactive tracer that binds to tau protein, can produce PET images that match the actual tau buildup found in the brain after death. It includes healthy volunteers and people with mild cognitive impairment or Alzheimer's dementia, all aged 50 or older. The goal is to see if this imaging method can reliably detect Alzheimer's-related brain changes, which could lead to better diagnosis without needing an autopsy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
[18F]-APN-1607, a radioactive tracer for PET imaging that binds to tau protein in the brain
What this could lead to
If successful, this could validate a PET scan as a reliable way to detect Alzheimer's-related brain changes in living people, potentially improving diagnosis and monitoring.
What could go wrong
The trial is small (12 participants) and early, so results may not be conclusive. The tracer's accuracy could be limited, and it involves radiation exposure from the PET scan.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Able to understand and voluntarily sign a written informed consent form (ICF). 2. Age≥50 years, male or female. 3. Charlson Comorbidity Index (CCI)≥5. 4. Able to tolerate imaging procedures. 5. For MCI or AD subjects: clinically diagnosed as AD-derived cognitive impairment or Alzheimer's dementia. 6. For HV subjects: no known personal or family history of AD-derived dementia. Exclusion Criteria: 1. Confirmed brain structural abnormalities that may affect PET reading, e.g., large stroke (infarct area\>4 cm) or intracranial space-occupying lesion. 2. Currently having clinically significant infectious diseases: HIV, hepatitis, etc. 3. Currently participating in any investigational clinical trial. 4. Previous participation in clinical studies of amyloid or tau-targeting agents. 5. Suspected hepatic encephalopathy. 6. Allergy to the investigational drug or any of its components. 7. Currently pregnant or breastfeeding. 8. Currently having a disease or condition that prolongs the QT interval.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer's disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Tiantan Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 100070, China

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