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Home spraying trial targets dengue, chikungunya, and zika in kids

NCT ID NCT04343521

Prevention Sponsor: Emory University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether spraying insecticide on indoor walls (Targeted Indoor Residual Spraying) can prevent diseases spread by Aedes mosquitoes, like dengue, chikungunya, and Zika. Over 4,400 children aged 2 to 15 in Merida, Mexico took part. Researchers tracked how many got sick over three transmission seasons to see if the spraying reduced infections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Targeted Indoor Residual Spraying (TIRS) with insecticide Actellic 300CS
What this could lead to
If effective, this spraying method could become a simple, low-cost way to prevent outbreaks of dengue, chikungunya, and Zika in high-risk areas.
What could go wrong
This is a completed trial, but results may not apply to other regions or mosquito species. The intervention requires residents to leave home briefly, which may not be practical everywhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

4,461 people

The number who actually took part.

Started

Nov 2020

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 15 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Household Level Inclusion Criteria: * Household is located within the bounds of a study cluster (5x5 city-block clusters) * City block has at least 60% premises that are residential Individual Level Inclusion Criteria: * 2 or more and up to 15 years of age at the time of initial enrollment * Living in a house that consented to TIRS (for children in TIRS cluster) Exclusion Criteria: Household Level Exclusion Criteria: * Households where study personnel identify a security risk (i.e., site where drugs are sold, residents are always drunk or hostile) * Sites where no residents spend time during the day (i.e. work 7days a week outside the home) * Inability for a resident to provide informed consent * Non-residential places (e.g., businesses, schools, markets, etc.) Individual Level Exclusion Criteria: * Less than 2 years of age or more than 15 years of age at the time of enrollment * Not living in a house that consented to TIRS (for children in TIRS cluster) * Having a medical condition that prevents implementation of study procedures * Temporary visitor to household * Plans to leave study area within next 12 months

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Conditions

The condition(s) this trial relates to.

Mosquito-Borne Diseases chikungunya prevention target dengue disease prevention target Zika virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aedes-borne diseases Chikungunya Dengue Zika

Contacts and locations

Locations

  • Universidad Autonoma de Yucatan

    Mérida, Yucatán, 97203, Mexico

More trials for these conditions

Other studies related to the condition(s) this trial covers.