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Tai chi for the brain: can a mindful exercise program slow memory loss?

NCT ID NCT04070703

Disease control Sponsor: Oregon Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether a specially designed tai ji quan program, called Tai Ji Quan: Moving to Maintain Brain Health, can slow cognitive decline in older adults with mild cognitive impairment. Participants will be randomly assigned to the tai ji quan program or a control exercise group for 24 weeks. The study measures changes in global cognitive function and the ability to perform tasks while walking, aiming to see if this mind-body exercise can protect brain health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a cognitively enhanced tai ji quan program called Tai Ji Quan: Moving to Maintain Brain Health
What this could lead to
If it works, this could point toward a non-drug way to slow memory loss and maintain independence in older adults at risk for dementia.
What could go wrong
This is a mid-stage trial with 318 participants, so results may not apply to everyone. The benefit may be small or not last beyond the 6-month study period.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

318 people

The number who actually took part.

Started

Oct 2019

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 95 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * complaint of memory loss * clinical dementia rating (CDR) scale score ≤0.5 * having normal general cognitive function screened, with MMSE ≥24 * capable of exercising safely, as determined by a healthcare provider * willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up Exclusion Criteria: * having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure * participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment

Contacts and locations

Locations

  • Oregon Research Institute

    Eugene, Oregon, 97403, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.