Could a new pill help kids fight hepatitis b?
NCT ID NCT02932150
First seen Dec 15, 2025 · Last updated Jun 22, 2026 · Updated 30 times
Summary
This study tests a drug called tenofovir alafenamide (TAF) in 150 children and teens with chronic hepatitis B. Half receive TAF and half receive a placebo for 24 weeks. Researchers are checking how safe the drug is, how the body processes it, and whether it lowers virus levels. The goal is to find a better treatment option for young patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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All India Institute of Medical Sciences
New Delhi, 110029, India
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American Research Corporation at Texas Liver Institute
San Antonio, Texas, 78215, United States
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Asan Medical Center
Seoul, 5505, South Korea
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Chang Gung Medical Foundation, Chang Gung Memorial Hospital, Linkou
Taoyuan, 33305, Taiwan
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Chang Gung Medical Foundation, Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, 83301, Taiwan
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Los Angeles
Los Angeles, California, 90027, United States
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Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cliniques Universitaires Saint-LUC UCL
Brussels, 1200, Belgium
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Federal Research Centre of Nutrition, Biotechnology and Food Safety
Moscow, 115446, Russia
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Federal State-Financed Institution Pediatric Research and Clinical Center for Infectious Diseases
Saint Petersburg, 197022, Russia
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Indiana University School of Medicine
Indianapolis, Indiana, 46202, United States
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Institute of Post Graduation Medical Education & Research
Kolkata, 700020, India
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Institutul National de Boli Infectioase "Prof.Dr. Matei Bals"
Bucharest, 21105, Romania
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 807, Taiwan
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Khalatkar Hospital
Nagpur, 440009, India
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Kyungpook National University Hospital
Daegu, 41944, South Korea
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LTMMC & LTMG Hospital
Mumbai, 400022, India
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Limited Medical Company Hepatolog
Tolyatti, 445009, Russia
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M. V Hospital and Research Center
Lucknow, 226003, India
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Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, 37232, United States
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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National Taiwan University Hospital
Taipei, 100, Taiwan
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Prince of Wales Hospital
Shatin, Hong Kong
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Rady Childrens Hospital
San Diego, California, 92123, United States
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Republican Clinical Hospital of Infectious Diseases named after A.F. Agafonov
Tatarstan, 420110, Russia
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SIDS Hospital and Research Centre
Surat, 395002, India
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Samsung Medical Center
Seoul, 6351, South Korea
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Samvedna Hospital
Varanasi, 221005, India
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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Seth GS Medical College and KEM Hospital
Mumbai, 400012, India
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Spitalul Grigore Alexandrescu-Sectia Pediatrie III
Bucharest, 11743, Romania
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Texas Children's Hospital - Main Hospital
Houston, Texas, 77030, United States
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The Children's Hospital at Montefiore
The Bronx, New York, 10467, United States
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University of California, San Francisco (UCSF)
San Francisco, California, 94158, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tenofovir alafenamide (TAF)
What this could lead to
If successful, this could provide a safe and effective treatment option for children with chronic hepatitis B, helping control the virus and reduce liver damage.
What could go wrong
This is an early-phase study with a small number of participants, so results may not apply to all children. The drug may not work better than placebo, and side effects are still being evaluated.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.