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Daily pills may ease painful stent symptoms

NCT ID NCT07206706

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two drugs—tadalafil and darifenacin—to see which better relieves bladder symptoms and pain caused by ureteric stents. 150 adults who had a stent placed after kidney stone treatment took each drug for three weeks in a crossover design. The goal was to find a more effective and tolerable option for managing these common side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tadalafil and darifenacin
What this could lead to
If one drug works better, it could offer a simple daily pill to reduce discomfort from ureteric stents.
What could go wrong
This is a small, early-phase trial with only 150 people. Results may not apply to everyone, and side effects like headache or dry mouth are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

150 people

The number who actually took part.

Started

May 2022

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age:18-40 years 2. Patient with ureteric stent size 6 Fr-26 cm post endoscopic procedure. Exclusion Criteria: 1. Known prostatic patient with LUTS 2. Pregnant or lactating women 3. Recurrent urinary tract infection. 4. Neurological diseases.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Management of ureteric stent related luts and pain

Contacts and locations

Locations

  • Ain Shams University Hospita

    Cairo, Cairo Governorate, 1151, Egypt