Can a common ED drug improve lung blood pressure?
NCT ID NCT06350773
First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times
Summary
This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with group 2 pulmonary hypertension (high blood pressure in the lungs). About 48 participants will take tadalafil or a placebo for 12 weeks. Researchers will measure how far they can walk in 6 minutes and check their heart function to see if the drug helps.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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66 people
The number who actually took part.
- Started
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Mar 2023
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * group 2 pulmonary hypertension with CpcPH with PVR equals or more than 4 by RHC. * NYHA II-III symptoms. * Patients should be on HF medical therapy 90 days before enrollment in the study. Exclusion Criteria: * All groups of PH, other than Group 2 PH. * Patients with Group 2, but no meeting the predefined hemodynamic criteria for CpcPH (mean PAP more than 20 mmHg, mean PCWP more than 15 mmHg, PVR equals or more than 4 WU). * Hypersensitivity, allergy, or intolerable side effects of PDE-5 inhibitors. * Contraindication to PDE-5 inhibitors, including current nitrate therapy. * Anticipated cardiac resynchronization therapy within 3 months of enrollment. * History of heart transplant, ventricular-assist device, or any other solid-organ transplant * Recent stroke, myocardial infarction, any coronary intervention; PCI or CABG. * Decompensated heart failure. * Female subject who is pregnant, breast-feeding, or unwilling to practice an acceptable method of birth control unless postmenopausal or sterile. * Unreliability as a study participant, based on the investigator's (or designee's) knowledge of the subject (e.g., alcohol or other substance abuse, inability or unwillingness to adhere to the protocol, documented noncompliance, or vulnerable population) * Current enrollment, or enrollment completed \<30 days previously, in another investigational drug or device clinical study. * Undergoing dialysis for end-stage renal disease. * End-stage liver disease comorbidities, limiting exercise tolerance. * Morbid obesity (body mass index \> 40). * Severe peripheral vascular disease with intermittent claudication. * Status after amputation of lower extremity(s) at any level. * Severe degenerative joint disease preventing normal walking. * Cerebrovascular accident with long-term sequelae affecting ability to walk.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beni Suef University
Cairo, Beni Suweif Governorate, 62511, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.