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Can a common ED drug improve lung blood pressure?

NCT ID NCT06350773

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This study tests whether tadalafil, a drug often used for erectile dysfunction, can help people with group 2 pulmonary hypertension (high blood pressure in the lungs). About 48 participants will take tadalafil or a placebo for 12 weeks. Researchers will measure how far they can walk in 6 minutes and check their heart function to see if the drug helps.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

66 people

The number who actually took part.

Started

Mar 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * group 2 pulmonary hypertension with CpcPH with PVR equals or more than 4 by RHC. * NYHA II-III symptoms. * Patients should be on HF medical therapy 90 days before enrollment in the study. Exclusion Criteria: * All groups of PH, other than Group 2 PH. * Patients with Group 2, but no meeting the predefined hemodynamic criteria for CpcPH (mean PAP more than 20 mmHg, mean PCWP more than 15 mmHg, PVR equals or more than 4 WU). * Hypersensitivity, allergy, or intolerable side effects of PDE-5 inhibitors. * Contraindication to PDE-5 inhibitors, including current nitrate therapy. * Anticipated cardiac resynchronization therapy within 3 months of enrollment. * History of heart transplant, ventricular-assist device, or any other solid-organ transplant * Recent stroke, myocardial infarction, any coronary intervention; PCI or CABG. * Decompensated heart failure. * Female subject who is pregnant, breast-feeding, or unwilling to practice an acceptable method of birth control unless postmenopausal or sterile. * Unreliability as a study participant, based on the investigator's (or designee's) knowledge of the subject (e.g., alcohol or other substance abuse, inability or unwillingness to adhere to the protocol, documented noncompliance, or vulnerable population) * Current enrollment, or enrollment completed \<30 days previously, in another investigational drug or device clinical study. * Undergoing dialysis for end-stage renal disease. * End-stage liver disease comorbidities, limiting exercise tolerance. * Morbid obesity (body mass index \> 40). * Severe peripheral vascular disease with intermittent claudication. * Status after amputation of lower extremity(s) at any level. * Severe degenerative joint disease preventing normal walking. * Cerebrovascular accident with long-term sequelae affecting ability to walk.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Beni Suef University

    Cairo, Beni Suweif Governorate, 62511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.