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Could a daily probiotic boost gum health in smokers?

NCT ID NCT07672379

Disease control Sponsor: Biruni University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a daily synbiotic supplement (probiotics plus prebiotic) to standard non-surgical gum treatment improves gum health in smokers with advanced periodontitis. 92 smokers and non-smokers will be split into four groups, receiving either the supplement or a placebo for 90 days. Researchers will measure gum pocket depth, attachment levels, and immune and bacterial markers to see if the supplement provides extra benefit.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
synbiotic supplement (probiotics and prebiotic inulin)
What this could lead to
If it works, this could point toward a simple, safe add-on to improve gum treatment outcomes for smokers with periodontitis.
What could go wrong
This is a small, early-stage trial with no phase designation. The supplement may show no added benefit over standard care, and results may not apply to non-smokers or other populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 92 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65 years * Diagnosis of generalized Stage III/IV Grade B/C periodontitis * Willingness to participate in the study and provide informed consent * No periodontal treatment within the last 3 months * No use of antibiotics or anti-inflammatory drugs within the last 3 months * Not being pregnant or breastfeeding * Presence of at least 20 teeth * Body mass index (BMI) between 18.5 and 30 kg/m² Exclusion Criteria: * Failure to meet voluntary participation requirements * Presence of systemic diseases affecting the periodontium or immune response * Use of additional dietary supplements * Pregnancy or breastfeeding * Use of immunosuppressive medications Individuals who may have difficulty complying with the study protocol

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Conditions

The condition(s) this trial relates to.

periodontal disorder periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontal disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Biruni University

    Istanbul, Istanbul, 34010, Turkey (Türkiye)

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