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Steady drip vs. shots: which helps heart surgery patients wake up faster?

NCT ID NCT04226495

Symptom relief Sponsor: University of Nebraska Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving the pain medicine sufentanil as a continuous drip during heart surgery helps patients wake up and leave the ICU sooner compared to giving it as single shots. 65 adults having planned heart surgery took part. The goal was to see if the drip method could reduce time on the breathing tube by at least 60 minutes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sufentanil
What this could lead to
If the infusion method works better, it could help patients wake up faster after heart surgery and shorten their time in the ICU.
What could go wrong
This is a small, single-center study with only 65 people, so results may not apply to everyone. The difference between the two methods might be small or not meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

65 people

The number who actually took part.

Started

Oct 2020

Finished

Oct 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled non-emergency cardiac surgical patients including those with planned procedures of CABG, AVR, and combined CABG and AVR * 19 to 80 years old * Planned pre-operative anesthesia screening visit and/or preoperative surgical clinic visit. * Inpatient subject that is scheduled (greater than 24hrs in advance) for a non-emergency cardiac surgical case Exclusion Criteria: * Sufentanil allergy * EF less than or equal to 30% * Moderate or severe right ventricular dysfunction, * Moderate pulmonary dysfunction, to include patients with at home 02 and/or daily bronchodilator therapy. * End Stage Renal Disease on Dialysis * Chronic Kidney Disease with GFR \<30 * Sternotomy Re-do * Emergency surgery * Greater than 4 units of RBCs or FFP combined * Mechanical circulatory support post-operatively such as ECMO, IABP, Impella * Not eligible for rapid wean extubation protocol * Requires infusion of sedative medication required during ICU admission * Greater than or equal to 15 minute ICU hold within PACU

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia

Contacts and locations

Locations

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.