New drug combo targets brain tumor fuel in early trial
NCT ID NCT03343197
First seen Feb 20, 2026 · Last updated Jun 18, 2026 · Updated 22 times
Summary
This early-phase study tested two experimental drugs, AG-120 and AG-881, in 49 adults with a recurrent, slow-growing brain tumor (low grade glioma) that has a specific IDH1 gene mutation. The goal was to see if these drugs could lower a substance called 2-HG in the tumor tissue before surgery. The study focused on safety and how the drugs work in the body, not on curing the disease.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
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Locations
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United States, California
Los Angeles, California, 90024, United States
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United States, California
San Francisco, California, 94143, United States
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United States, Massachusetts
Boston, Massachusetts, 02215, United States
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United States, New York
New York, New York, 10065, United States
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United States, North Carolina
Durham, North Carolina, 27710, United States
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United States, Texas
Dallas, Texas, 75390, United States
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.