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Can a watercress drink help flush out Cancer-Causing chemicals?

NCT ID NCT03978117

Disease control Sponsor: Masonic Cancer Center, University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether two specially prepared drinks, one made from freeze-dried watercress, can help the body get rid of harmful environmental chemicals that may cause cancer. Three hundred healthy adults, including smokers and non-smokers, drank the preparations three times daily for two weeks. Researchers measured detoxification byproducts in urine to see if the drinks boosted the body's natural cleansing process, especially in people with certain gene variations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Freeze-dried watercress preparation (providing 2-phenethyl isothiocyanate, PEITC)
What this could lead to
If it works, this could point toward a simple dietary drink that helps the body remove cancer-causing chemicals from the environment.
What could go wrong
This is a small, early-phase trial in healthy people, not patients. The drink may not produce meaningful detoxification, and results may not apply to the general population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

300 people

The number who actually took part.

Started

Feb 2021

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult Male or female. Participants can be smokers or non-smokers * In good physical health * In stable and good mental health * Not using any medications that may affect the Nrf2 pathway * Women who are not pregnant or nursing or planning to become pregnant * Participants have provided written informed consent to participate in the study Exclusion Criteria: * Significant immune system disorders, respiratory diseases, kidney or liver diseases or any other medical disorders that may affect biomarker data as determined by the licensed medical professional * Vital signs outside of the allotted range * Not willing to abstain from eating cruciferous vegetables during the course of the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • University of Minnesota

    Minneapolis, Minnesota, 55405, United States

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