Body's own cells injected into knee tendon shows promise
NCT ID NCT04753853
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested an injection of stromal vascular fraction, a mixture of cells from the patient's own fat tissue, for patellar tendinopathy (jumper's knee). Thirty participants received the injection under ultrasound guidance. The goal was to see if it could improve symptoms and function, measured by a questionnaire called VISA-P.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- stromal vascular fraction injection
- What this could lead to
- If it works, this could offer a new treatment option for patellar tendinopathy that uses the body's own cells to help heal the tendon.
- What could go wrong
- This was a small, early study with only 30 participants and no comparison group. The results may not apply to everyone, and the procedure may not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
30 people
The number who actually took part.
- Started
-
Jul 2021
- Finished
-
May 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 60 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ultrasound or MRI signs of patellar tendon pathology Exclusion Criteria: * BMI \> 30 * Patients suffering from: rheumatic diseases, diabetes, infectious processes, epilepsy, severe osteoporosis * Patients undergoing intra-tendon infiltration of another substance within the previous 6 months; * Patients who had patellar tendon surgery within the previous 12 months; * Immunodepression * On going systemic inflammatory diseases (stabilized outcomes of such diseases are not considered absolute contraindications).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Istituto Ortopedico Rizzoli
Bologna, 40124, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Tendon pain showdown: which injection works better?