Could 5 radiation sessions be as good as 30 for skin cancer?
NCT ID NCT07337161
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a shorter, more intense type of radiation (stereotactic radiotherapy given in 5 sessions) works as well as the standard longer course (20-30 sessions) for treating skin cancer that has spread to the parotid gland in the head and neck. About 90 adults who have had surgery to remove the cancer will take part. The goal is to see if the shorter treatment controls the cancer just as well with fewer side effects.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2025
- Expected to finish
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Sep 2035
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria * Age ≥ 18 years * Patient able to provide informed consent * Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Patient is a candidate for curative intent treatment * Patient is able to comprehend English adequately to complete patient reported outcome questionnaires * Biopsy-confirmed cutaneous SCC * Definitive resection of a primary cutaneous tumor within the head and neck * Tumor stage T1-T4 (AJCC 8th edition); or tumor stage unknown (T0/Tx) with a positive intraparotid, peri-parotid or cervical node that is assumed to be from a head and neck cutaneous SCC by the treating oncologist * Nodal stage N1-N3 (AJCC 8th edition) * At least 1 indication for adjuvant radiation, including: * T3 or T4 tumor stage * Lymphovascular invasion (LVI) * Perineural invasion (PNI) * Positive or close (≤ 3 mm) margin * ≥ 1 positive intraparotid, peri-parotid or cervical lymph node * Multiple local recurrences or multi-focal disease * Neoadjuvant or adjuvant immunotherapy is allowed Exclusion criteria * Definite metastatic disease at diagnosis * Pregnant or breastfeeding women * Significant health conditions or contraindications to receiving surgery and radiation * History of previous head and neck cancer within 5 years, except for localized skin cancers (i.e. no nodal or distant spread) * Prior head and neck radiation involving the ipsilateral parotid or neck. However, prior radiation to the index skin cancer that has led to the parotid nodal disease being treated on this trial is allowed, as long as there is no overlap, or inconsequential overlap, in the judgement of the treating oncologist. * Indications for contralateral neck radiation (i.e. contralateral or bilateral lymph nodes) * Previous invasive malignancy within 5 years, unless controlled with no evidence of disease
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Verspeeten Family Cancer Centre
RECRUITINGLondon, Ontario, N6A 5W9, Canada
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