Lung cancer patients get a second shot: CyberKnife boost after chemoradiation

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients aged 18 years old or more 2. ECOG 0 to 2 3. Histologically proven non-small cell lung cancer 4. Stage III non-metastatic tumor, not allowing for immediate surgery 5. Volume(s) on the evaluation chest CT scan done at the end of conventional radiotherapy (between 34 \& 46 Gy) meeting the following criteria: * 1 to 3 target volumes of less than 5 cm in greatest diameter * And allowing for the delivery of a CyberKnife boost to be carried out in compliance with the manufacturer requirements and with the doses delivered to the organs at risk (OAR/fractions) defined in appendix 2 6. Patients who have received a " Taxcis " treatment consisting in 2 cycles of induction chemotherapy (platinium-based doublet) and then at least 40 Gy of irradiation in combination with at least 2 cycles of concomitant chemotherapy (platinium-based doublet) 7. No contraindication to implantable venous devices (IVDs) 8. Patient who has read the patient information note and signed the consent form 9. If applicable, negative pregnancy test\* 10. Eligible for National Health Insurance in France 11. Chest CT scan performed prior to Taxcis Exclusion Criteria: 1. Positive EGFR mutation 2. Exercise-induced dyspnea associated with heart failure equal to or greater than stage III of the New York Heart Association (NYHA) classification, (appendix 3) 3. Coronary syndrome or heart failure in the last three months 4. Pulmonary function test contraindicating radiotherapy: PFT-FEV1 inferior to 1 L. 5. After radio-chemotherapy, presence of any toxicity contraindicating Cyberknife irradiation 6. Vulnerable populations and participants as defined in Articles 64 to 68 of Regulation (EU) 2017/745 of the European Parliament and of the Council of 5 April 2017: * Incapacitated participants who have not given or refused informed consent prior to the onset of their incapacity, who are not under the provisions of article 64 ; * Pregnant or breast-feeding women who are not covered by the provisions of article 66 ; * Adults under legal protection or unable to express their consent.